TY  - JOUR
T1  - Analysis of Synonymous Codon Usage in Dengue Viruses
AU - Liu, Yong-Sheng AU - Ma, Jun-Jun AU - Zhao, Feng AU - Zhang, Jie AU - Zhou, Jian-Hua AU - Ma, Li-Na AU - Ding, Yao-Zhong AU - Chen, Hao-Tai AU - Gu, Yuan-Xing 
JO  - Journal of Animal and Veterinary Advances
VL  - 12
IS  - 1
SP  - 88
EP  - 98
PY  - 2013
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2013.88.98
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2013.88.98
KW  - Dengue virus
KW  -relative synonymous codon usage
KW  -effective number of codons
KW  -significant factor
KW  -codon usage pattern
KW  -codon usage bias
KW  -mutation pressure
AB  - Dengue Viruses (DENV) are the most common arboviral pathogens 
  in tropical and subtropical regions of the world. Analysis of codon usage patterns 
  of DENV can reveal much about the molecular evolution of the viruses. The codon 
  usage patterns of 119 samples of DENV were analysed including the Relative Synonymous 
  Codon Usage (RSCU) and Codon Usage Bias (CUB). The overall extent of codon usage 
  bias is low in DENV. The codon usage patterns of the 4 serotypes of DENV are 
  significant different indicating that the evolutionary genetics of them are 
  independent. Compositional constraint is a significant factor that affects codon 
  usage variation. Mutation pressure is the main factor in codon usage variation 
  of these viruses. Furthermore, natural selection may play a role in codon usage 
  pattern of DENV as well. However, more comprehensive analysis is needed for 
  show the deeper characteristic of synonymous codon usage and other responsible 
  factors of codon usage bias in DENV.
ER  -