TY  - JOUR
T1  - Effects of Resveratrol on Testis Damage in Streptozotocin Induced Diabetic 
  Rats
AU - Yulug, Esin AU - Tured, Sibel AU - Alver, Ahmet AU - Kutlu, Omer AU - Karaguzel, Ersagun AU - Kahraman, Cemil 
JO  - Journal of Animal and Veterinary Advances
VL  - 12
IS  - 6
SP  - 747
EP  - 753
PY  - 2013
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2013.747.753
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2013.747.753
KW  - Diabetes mellitus
KW  -resveratrol
KW  -apoptosis
KW  -testis
KW  -rat
AB  - Oxidative stress is known to play an important role in the 
  pathogenesis of diabetes. Resveratrol has antioxidant and antidiabetic effects. 
  This study purposed to evaluate the protective effect of resveratrol against 
  testicular injury in streptozotocin-induced diabetic rats. Twenty four male 
  Sprague Dawley rats were randomly divided into four groups: control, Resveratrol 
  (RSV), Diabetes (DM) and DM+RSV groups. DM group was induced by a single intraperitoneal 
  (i.p.) injection of streptozotocin (60 mg kg<SUP>-1</SUP>). RSV and DM+RSV groups 
  were administered 20 mg kg<SUP>-1</SUP> resveratrol i.p. per day. All rats were 
  sacrificed at the end of the 14th day. Testis tissues and blood samples were 
  collected for biochemical and histopathological examination. At the end of the 
  1st and 2nd weeks, blood sugar levels rose significantly in the DM and DM+RSV 
  groups. These levels also decreased significantly in the DM+RSV group compared 
  to the DM group. Tissue malondialdehyde levels rose significantly in the DM 
  and DM+RSV groups, compared to the control and RSV groups and decreased in the 
  DM+RSV group compared to the DM group but this decrease was not significant. 
  According to Johnsen&#146;s tubular 
  biopsy scoring, spermatogenesis decreased in the DM group, increased in the 
  DM+RSV group compared to the DM group significantly. Apoptotic index in seminiferous 
  tubule cells increased in the DM and DM+RSV groups compared to the control group 
  and decreased in the DM+RSV group compared to the DM group significantly. The 
  findings show that DM increases oxidative stress and testicular damage. RSV 
  protects DM-induced oxidative testicular damage at the histopathological and 
  apoptotic level, in particular by reducing blood sugar levels.
ER  -