TY  - JOUR
T1  - A Comparison of the Emetic Toxicity of Deoxynivalenol and
Acetyl Deoxynivalenol in House Musk Shrews (<I>Suncus murinus</I>)
AU - Arai, Sachiko AU - Itoh, Seigo AU - Watabnabe, Maiko AU - Sunaga, Fujiko AU - Konishi, Sugita- 
JO  - Journal of Animal and Veterinary Advances
VL  - 12
IS  - 6
SP  - 718
EP  - 720
PY  - 2013
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2013.718.720
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2013.718.720
KW  - Emesis
KW  -deoxynivalenol
KW  -3-acecylnivalenol
KW  -15-acecylnivalenol
KW  -Probit Method
AB  - The emetic toxicities of deoxynivalenol and its acetyl derivatives 
  were examined using house musk shrews (<I>Suncus murinus</I>). Emesis was observed 
  after the oral administration of these toxins at doses ranging from 0-40 mg 
  kg<SUP>-1</SUP> B.W. The Effective Dose (ED) causing emesis was calculated using 
  the Probit Method. The ED 50 of deoxynivalenol, 3-acetylnivalenol and 15-acetylnivalenol 
  was 3.85, 0.87 and 8.85 mg kg<SUP>-1</SUP> B.W., respectively. The results show 
  that the emetic toxicity of 3-acetylnivalenol is 10 times higher than that of 
  deoxynivalenol or 15-acetyl deoxynivalenol. Even though, acetyl deoxynivalenol 
  has been determined to exhibit equivalent toxicity to deoxynivalenol by the 
  FAO/WHO Joint Food Additives Committee, the different responses of acute emetic 
  toxicity should, therefore be taken into account.
ER  -