TY  - JOUR
T1  - Induced Multipotent Stem Cells Combining with HAP/TCP/CS Composite Scaffold Repairs Bone Defect
AU - Chen, Qing-Hua AU - Zhu, Xiang-Qing AU - , Li Lei AU - , Qiong Wu AU - , Qiang Wang AU - , Cui-Zhu Chen AU - , Xue-Min Cai AU - , Rong-Qing Pang AU - , Xing-Hua Pan 
JO  - Journal of Animal and Veterinary Advances
VL  - 12
IS  - 5
SP  - 573
EP  - 580
PY  - 2013
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2013.573.580
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2013.573.580
KW  - Induced multipotent stem cells
KW  -scaffold
KW  -cell hybrid material
KW  -bone defect
KW  -repairin
AB  - The treatment of bone defect is the multi-disciplinary clinical 
  problem. Although, several types of bone graft materials are used for clinical 
  study, numerous hurdles such as infection and immune rejection need to be resolved 
  in essence. Various types of stem cells combining with biological material for 
  repairing bone defect is a promising way. However, the poor resource of stem 
  cells has restricted their clinical application. In earlier research, researchers 
  had reported that transient <I>in vitro</I> epigenetic reprogramming of mouse 
  skin fibroblasts into multipotent stem cells. In this study, researchers used 
  the similar method to reprogram dog skin fibroblasts into multipotent stem cells. 
  Further, reprogrammed cells were re-differentiated into osteogenesis-like cells 
  <I>in vitro</I>. Especially, iMS cells combining with Hydroxyapatite/&#946;-Tricalcium 
  Phosphate/Chitosan (HAP/&#946;-TCP/CS) Composite Scaffold could repair bone 
  defect in dog. The results indicated that the iMS could be used as seed cell 
  for repairing bone defect in clinical application.
ER  -