TY  - JOUR
T1  - Immunogenicity and Protective Efficacy of a Attenuated Salmonella-Vectored Vaccine Expressing Esat6 Against Tuberculosis in Mice
AU - Liu, Xudong AU - Wang, Shi AU - Di, Yuan 
JO  - Journal of Animal and Veterinary Advances
VL  - 12
IS  - 4
SP  - 504
EP  - 508
PY  - 2013
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2013.504.508
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2013.504.508
KW  - Mycobacterium tuberculosis
KW  -Salmonella-vectored vaccine
KW  -Esat6
KW  -efficacy
KW  -cellular immunity
AB  - It is a need to develop protective vaccines against Tuberculosis (TB) that elicit full immune responses including mucosal immunity. Here an attenuated Salmonella-vectored vaccine expressing Esat6 of the <I>Mycobacterium tuberculosis</I> (Mtb) were constructed. These vaccine were assessed for their immunological efficacy on Specific Pathogen-Free (SPF) mice challenged with Mtb. The experimental data demonstrated that this SL(E6) vaccine and BCG could induce the stronger TB Ag-specific mucosal, humoral and cellular immune responses and exerted high protective efficacy in mice against virulent Mtb H37Rv challenge compared to the other vaccinated groups (mice immunized with Esat6, a DNA vaccine or BCG only). These data may represent a novel promising Salmonella vaccine candidate for the prevention of TB.
ER  -