TY  - JOUR
T1  - Mangiferin Induces Apoptosis and Cell Cycle Arrest in MCF-7 Cells Both <I>in vitro</I> and <I>in vivo</I>
AU - Lv, Jianzhen AU - Wang, Zijie AU - Zhang, Li AU - Wang, Hai-Lian AU - Liu, Yuande AU - Li, Chunyang AU - Deng, Jiagang AU - , Yi-Wang AU - Bao, Jin-Ku 
JO  - Journal of Animal and Veterinary Advances
VL  - 12
IS  - 3
SP  - 352
EP  - 359
PY  - 2013
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2013.352.359
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2013.352.359
KW  - Mangiferin
KW  -cdc2-cyclinB1 singling pathway
KW  -PKC-NFkB pathway
KW  -drugs
KW  -tumor
AB  - Mangiferin, a C-glucosylxanthone (1, 3, 6, 7-tetrahydroxyxanthone-C2-&#946;-D-glucoside) purified from plant sources was shown to have <I>in vitro</I> growth-inhibitory and apoptosis-inducing activity against MCF-7 cells and it also possessed anti-tumor property on MCF-7 xenograft mice <I>in vivo</I>. Mangiferin triggered G<SUB>2</SUB>/M phase cell-cycle arrest via down-regulating cdc2-cyclinB1 singling pathway and induced apoptotic cell death through inhibiting PKC-NF&#954;B pathway in human breast carcinoma MCF-7 cells. In addition, mangiferin had anti-cancer effects <I>in vivo</I> and it could decrease the volume and weight of subcutaneous tumor mass obviously as well as expanded lifespan of xenograft mice. With the molecular mechanisms of mangiferin-induced anti-tumor activities were gradually clarified, traditional Chinese medicine would become potential anti-neoplastic drugs in future cancer therapeutics.
ER  -