TY  - JOUR
T1  - Abnormal Follicle Development in GGPPS Conditional Knockout Mice
AU - Liu, Honglin AU - Song, ChunLei AU - Wang, XiuXing AU - Wang, Xuguang AU - Ma, Xueshan AU - Zhang, Jun AU - Gao, BeiBei 
JO  - Journal of Animal and Veterinary Advances
VL  - 12
IS  - 3
SP  - 323
EP  - 329
PY  - 2013
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2013.323.329
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2013.323.329
KW  - ggpps
KW  -conditional knockout
KW  -follicular development
KW  -multi-oocyte follicles
KW  -IPP
AB  - GGPPS is a member of prenyl transferase family catalyzing the synthesis of GGPP (Geranylgeranyl diphosphate) from Farnesyl diphosphate (FPP) and Isopentenyl diphosphate (IPP). Using cre/loxp system, researchers got oocyte specific knockout ggpps mice. Mutation of ggpps resulted in abnormality of follicular development, granulosa cell premature luteinization, theca cell hypertrophy and multi-oocyte follicles. Interaction of oocyte and granulosa cell was also changed. Oocyte-specific knockout of ggpps mice was acquired. Follicles grew abnormally in ggpps mutation mice. Interaction of oocyte and granulosa cell was also changed.
ER  -