TY  - JOUR
T1  - Evaluation of Lysine and Lysine-Lactoferrin Association in Cats Infected by Feline Herpesvirus-1
AU - Vincenzo, Cuteri AU - Monia, Bordi AU - Fulvio, Laus AU - Matteo, Cerquetella AU - Silvia, Preziuso AU - Ilenia, Copponi AU - Andrea, Spaterna 
JO  - Journal of Animal and Veterinary Advances
VL  - 12
IS  - 2
SP  - 181
EP  - 185
PY  - 2013
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2013.181.185
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2013.181.185
KW  - cat
KW  -feline infectious rhinotracheitis
KW  -Feline herpesvirus type 1
KW  -lysine
KW  -lactoferrin
AB  - Feline Herpesvirus type 1 (FHV-1), the causative agent of 
  feline infectious rhinotracheitis is a high widespread virus. At the present, 
  treatment is aspecific and symptomatic, often based on collateral antibiotic 
  treatment. The antiviral effect of lysine, an essential basic amino acid has 
  been widely investigated and is related to a competitive inhibition against 
  arginine. Lactoferrin is a glycoprotein of the transferrin family that seems 
  able to prevent the internalization process and to inhibit viruses replication 
  within the host cells. The aim of the present study was to verify the efficacy 
  of lysine alone and of the association lysine-lactoferrin against FHV-1 in cats. 
  For this purpose, four groups of five FHV-1 infected cats each were treated 
  with different products and monitored at different time points clinically and 
  virologically. In particular, patients received the association lysine-lactoferrin 
  per os (group 1), the association lysine-lactoferrin via aerosol (group 2), 
  only lysine per os (group 3) and the association amoxicillin-clavulanic acid 
  (group 4). Four patients of group 1 (80%), 3 of group 2 (60%), 3 of group 3 
  (60%) and 5 of group 4 (100%), clinically improved till a complete remission 
  of systemic condition and respiratory symptoms. Viral shedding in oculo-conjunctival 
  samples gradually decreased in almost all cats. These data suggest that the 
  association lysine-lactoferrin could be a first choice in FHV-1 infected cats 
  for reducing clinical signs and viral shedding. Antibiotics should be used only 
  when non-antibiotic products are not sufficient in limiting the secondary bacterial 
  infections.
ER  -