TY  - JOUR
T1  - Effects of Dietary Addition of β-Glucan on Pigs Infected with Salmonella Typhimuriu
AU - Kim, Won-Il AU - Shabir, Nadeem AU - Yoon, Byung-Dae AU - Khatun, Amina AU - Kim, Bum-Seok AU - Shin, Ji-Hoon AU - Ahn, Keug-Hyun 
JO  - Journal of Animal and Veterinary Advances
VL  - 12
IS  - 23
SP  - 1657
EP  - 1664
PY  - 2013
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2013.1657.1664
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2013.1657.1664
KW  - β-glucan
KW  -genkwadaphnin
KW  -Aureobasidium pullan
KW  -Salmonella Typhimurium
KW  -weaned pigs
AB  - Although, the antimicrobial effects of &#946;-Glucan (BG) have been described previously, the use of &#946;-glucan in food animal production has been unrealistic due to high production costs. Recently, pure &#946;-glucan could be efficiently produced by cultivating mutant <I>Aureobasidium pullans</I> which contains a disrupted <I>pul</I> gene and the new method can simplify purification process and reduce mass production costs. Thus, the effect of the &#946;-glucan purified from mutant <I>A. pullans</I> on salmonella infection in weaned pigs was evaluated in the study. Twenty, 4 weeks old pigs were randomly assigned to the following 4 groups: BG or BG-X group was provided with commercial feeds containing &#946;-glucan (10 mg kg<SUP>-1</SUP>) or containing both &#946;-glucan (10 mg kg<SUP>-1</SUP>) and Genkwadaphnin (10 mg kg<SUP>-1</SUP>), respectively; Normal Feed (NF) and Negative control (Neg.) groups were only provided with commercial feeds only. All the groups were provided with their specific diets for 2 weeks, challenged with Salmonella Typhimurium at 10<SUP>8</SUP> Colony Forming Units (CFU)/mL except for the Neg. group and sacrificed for pathological evaluation at 4 weeks after the challenge. As compared with the NF group, BG and BG-X groups showed significantly lower diarrhea incidence and salmonella shedding in feces and gained more weight after salmonella infection. Gross lesions were less severe in BG and BG-X groups but the differences reached no statistical significance. In conclusion this study demonstrated that the overall performance of weaned pigs fed &#946;-glucan derived from <I>A. pullan</I> was enhanced upon challenge with salmonella by increasing weight gains and reducing both the incidence of diarrhea and fecal shedding of salmonella.
ER  -