TY  - JOUR
T1  - Effects of Selenium Overexposure on Glutathione Peroxidase and Selenoprotein <I>W</I> Gene Expression in the Jejunum
AU - Zhang, Qin AU - Liu, Bitao AU - Zheng, Liangyan AU - Tang, Zhaoxin 
JO  - Journal of Animal and Veterinary Advances
VL  - 12
IS  - 22
SP  - 1628
EP  - 1631
PY  - 2013
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2013.1628.1631
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2013.1628.1631
KW  - Selenium
KW  -antioxidant
KW  -overexposure
KW  -mRNA
KW  -GPx2
AB  - Researchers determined how oxidative stress induced by excess Se alters expression of selected selenoproteins in the jejunum from mice fed diets of different Se content. Deficient Se diet downregulated the mRNA level of GPx1, GPx4 and SEPW1; super nutrition Se dramatically increased the level of GPx1 and SEPW1 mRNA levels but had no effect on GPx2 mRNA level. The excess Se diet led to decrease GPx1 and SEPW1 mRNA levels but had little effect on the level of GPx4 mRNA. The data show that mRNA levels of the GPx family or selenoprotein W are differentially regulated by dietary Se.
ER  -