TY  - JOUR
T1  - Studies on the Pharmacokinetics of Melamine in Dairy Goat
AU - , Wang-Liang AU - Ming-Wu, Jin AU - Weiwei, Zhang AU - Yong-Gen, Zhang 
JO  - Journal of Animal and Veterinary Advances
VL  - 12
IS  - 14
SP  - 1217
EP  - 1219
PY  - 2013
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2013.1217.1219
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2013.1217.1219
KW  - Melamine
KW  -pharmacokinetics
KW  -dairy goat
KW  -HPLC
KW  -goat
AB  - This experiment was conducted to study the pharmacokinetics 
  of melamine in dairy goat. A single intravenous administration of the melamine 
  at the dose of 6.13 mg kg<SUP>-1</SUP> B.W. to 6 dairy goats. Blood samples 
  were collected at different intervals after administration and concentrations 
  of melamine were determined by HPLC Method. The plasma concentration-time data 
  of melamine was analyzed by Pharmaceutical 3P97. The results showed that two-compartment 
  open model was the optimum one of melamine in the dairy goats. The main pharmacokinetic 
  parameters were as follows: V<SUB>d</SUB> was (0.03&plusmn;0.01) L kg<SUP>-1</SUP>, 
  t<SUB>1/2&#946;</SUB> was (3.64&plusmn;0.02) h, AUC was (41.96&plusmn;0.52) 
  &#956;g h mL<SUP>-1</SUP>, Cl was (0.14&plusmn;0.01) L kg<SUP>-1</SUP> h<SUP>-1</SUP>. 
  These results indicated that the distribution of melamine in dairy goat was 
  limit and the elimination of melamine was rapid.
ER  -