TY  - JOUR
T1  - Tachyplesin I Induce Drug Resistance in Bacteria <I>in vitro</I>
AU - Guan, W.T. AU - Hong, J. AU - Dai, J.G. AU - Jin, G. AU - Huang, Zh.L. AU - Zhang, L.J. AU - Dang, J. Zh. AU - Zhang, Y. 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 7
SP  - 939
EP  - 945
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.939.945
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.939.945
KW  - Antimicrobial peptides
KW  -resistance
KW  -tachyplesin I
KW  -Escherichia coli
KW  -Staphylococcus aureus
KW  -China
AB  - Tachyplesin I is a 17 amino acid cationic antibacterial peptide with a typical cyclic antiparallel &#946;-sheet structure. It is not clear whether tachyplesin I can induce resistance in bacteria. Therefore, two selection procedures by gradually increasing the induction concentration of tachyplesin I were performed to determine whether tachyplesin I could induce resistance in <I>Escherichia coli</I> and <I>Staphylococcus aureus in vitro</I>. The results showed that tachyplesin I did not induce resistance in <I>Escherichia coli</I> ATCC25922, F41 and <I>Staphylococcus aureus </I>ATCC25923 in this study whereas high resistance to benzylpenicillin was induced using the same procedures in <I>Staphylococcus aureus</I> ATCC25923. Furthermore, no cross-resistance between tachyplesin I and benzylpenicillin was observed. It is suggested that tachyplesin I may be a safe antibacterial agent for future use in clinical practice.
ER  -