TY  - JOUR
T1  - Dynamics of Cytokines Associated with IL-17 Producing Cells in Serum and Milk in Mastitis of Experimental Challenging with <I>Staphylococcus aureus</I> and <I>Escherichia coli</I> in Dairy Goats
AU - Chen, D.K. AU - Jing, X.Q. AU - Zhao, Y.Q. AU - Shang, C.C. AU - Yao, Y.L. AU - Tian, T.T. AU - Li, J. 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 4
SP  - 475
EP  - 479
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.475.479
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.475.479
KW  - IL-17
KW  -mastitis inflammation
KW  -dairy goats
KW  -cytokines
KW  -China
KW  -ELISA kits
AB  - Interleukin-17 is a critical pro-inflammatory cytokine in the development of autoimmunity and the immune responses against infection of bacteria, fungus and parasites. In the present study, dynamics of IL-17 and cytokines associated with IL-17 producing in serum and milk in experimental mastitis challenged with <I>S. aureus</I> and <I>E. coli</I> in dairy goats were monitored using commercial ELISA kits. The results showed that the levels of IL-17 in milk were peaked at 24 or 48 h post challenged with <I>E. coli</I> or <I>S. aureus</I>, respectively but no detectable peak was found in serum. The levels of TGF-&#946;, IL-6 and IL-1&#946; in milk were elevated in goats challenged with <I>E. coli</I> or <I>S. aureus</I> but only slight fluctuant were found in serum. These indicated that IL-17 was an important cytokine in the inflammation development of dairy goat mastitis challenged with <I>E. coli</I> or <I>S. aureus</I> and the local pro-inflammatory cytokines milieu plays an important role in the development of subclinical mastitis whether infected with <I>E. coli</I> or <I>S. aureus</I>.
ER  -