TY - JOUR T1 - Association Between Enrofloxacin and N-Acetylcysteine in Recurrent Bronchopneumopathies in Dogs Caused by Biofilm Producer Bacteria AU - Cuteri, Vincenzo AU - Spaterna, Andrea AU - Laus, Fulvio AU - Pampurini, Fabrizio AU - Cerquetella, Matteo AU - Attili, Anna Rita JO - Journal of Animal and Veterinary Advances VL - 11 IS - 4 SP - 462 EP - 469 PY - 2012 DA - 2001/08/19 SN - 1680-5593 DO - javaa.2012.462.469 UR - https://makhillpublications.co/view-article.php?doi=javaa.2012.462.469 KW - enrofloxacin KW -therapy KW -biofilms KW -dog KW -Chronic bronchopneumopathy KW -N-acetylcysteine AB - To evaluate the efficacy of enrofloxacin and N-acetylcysteine combination in the treatment of recurrent bronchopneumopathies caused by biofilm producer bacteria, a total of 30 dogs with recurrent respiratory diseases were examined. Bronchoalveolar lavage fluid of each animal was submitted to bacteriological and cytological examinations. Twelve patients have been treated with the above mentioned combination orally or by using an aerosol. Three dogs were randomly selected to be orally treated with Enrofloxacin only and another group of three animals has been randomly chosen to test the treatment with N-acetylcysteine only. Moreover, the in vitro sensitivity towards a panel of antibiotics for both biofilm and not biofilm producing bacteria was evaluated and correlation between bacterial sensitivity and biofilm production was evaluated. One animal was bacteriologically negative while biofilm producer bacteria have been identified in 19 (65.5%) out of the 29 bacteriological positive dogs. Biofilm formation and its abundance decreased bacterial sensitivity towards enrofloxacin (p<0.01) and cephalosporin (p = 0.031) while significant differences were not observed for the other classes of antibiotics. The association showed to be safe and effective in eliminating biofilm producer bacteria from all treated animals. ER -