TY  - JOUR
T1  - Comparison of Effect of Non-Specific Filtering Methods and their Combinations on GeneChip Data Analysis: A Case for Affymetrix Porcine Genome Microarray
AU - Zhu, Meng-Jin AU - Zhao, Ming AU - Chen, Hong-Bo AU - Liu, Xiang-Dong AU - Wang, Chao AU - Guo, Jing-Ying AU - He, Min-Hui AU - Zhao, Shu-Hong 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 24
SP  - 4593
EP  - 4598
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.4593.4598
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.4593.4598
KW  - Non-specific filtering
KW  -differentially expressed gene
KW  -Affymetrix GeneChip data
KW  -pig
KW  -China
AB  - Microarray technology has been widely applied in the research 
  area of animal genetics and breeding. In the earlier stage of microarray data 
  analysis, the non-specific filtering is a common procedure which has been used 
  increase the detection rate of differentially expressed genes. In this investigation, 
  researchers use the data from Affymetrix GeneChip Porcine Genome Array to comparatively 
  assess the effects of different non-specific filtering methods on the results 
  of transcriptome analysis. The research results showed that the MAS5, ET and 
  IQR filters could increase but the I/NI-calls method could decrease the number 
  of differentially expressed genes. Here into, the IQR filter has the largest 
  detection rate. Furthermore, the two-way combinations with IQR filter have the 
  similar increasing effect on differentially expressed gene detection. It is 
  concluded that not all non-specific filtering methods could increase the detection 
  rate in microarray data analyses and the IQR filter could be considered as a 
  preferred choice when improvement in the detection rate is needed on some occasions.
ER  -