TY  - JOUR
T1  - The Toxicity Effect of Vincristine at During Pregnancy in Newborn Mice
AU - Hejazi, Sajjad 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 24
SP  - 4497
EP  - 4500
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.4497.4500
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.4497.4500
KW  - Pregnancy
KW  -teratology
KW  -vincristine
KW  -experimental group
KW  -significant
AB  - Vincristine is an alkaloid derived from <I>Vinca rosea</I> 
  that its mechanism is to stop the mitosis cell cycle. Therefore, this drug is 
  used in chemical treatment with high multiplication as ovarian cancer, cervical 
  cancer and mammary cancer. This drug can have teratologic effects on fetus. 
  But there is not enough information about pregnant women. Therefore, researchers 
  have been tried in this study to evaluate the toxic effects of this drug in 
  pregnant women on the newborn infants. In this study, researchers choose 40 
  pregnant mice and sampling units consists of the newborn infants. Firstly, the 
  female mice have been placed near male mice and after observing the vaginal 
  plaque, pregnant mice&#146;s were divided randomly into 2 groups as control 
  and experimental. Mice&#146;s of the experimental group were injected by vincristine 
  (3 mg kg<SUP>-1</SUP>-IP) on day 10th and 16th of gestation. The control group 
  received distilled water. After parturition, the newborn infants were evaluated 
  by the parameters of external morphology anomaly and the data was evaluated 
  by t-test test and SPSS Software. The analysis of the statistics showed that 
  the use of vincristine at during pregnancy on the newborn infants was teratologic 
  effects. In comparing the average of the parameters in the experimental group 
  with control group, there was significant difference (p&lt;0.001).
ER  -