TY  - JOUR
T1  - Immunohistochemical Study of the Effect of Resveratrol on the Expression 
  of β-Catenin Protein in Experimental Colonic Carcinoma of Rat
AU - Doustar, Yousef AU - Garjani, Alireza 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 23
SP  - 4472
EP  - 4475
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.4472.4475
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.4472.4475
KW  - B-catenin proteins
KW  -colon carcinoma
KW  -resveratrol
KW  -rat
KW  -ketamine
AB  - Colorectal cancer is a major health problem worldwide. Resveratrol 
  is a stilbenoid, a type of natural phenol and a phytoalexin produced naturally 
  by several plants when under attack by pathogens such as bacteria or fungi. 
  The main objective of present study was to immunohistochemical assessment of 
  the effect of resveratrol on the expression of β-catenin protein in experimental 
  colonic carcinoma of rat. The 25 male Wistar rats aged 3-4 months old weighting 
  250-350 g were selected by chance. The rats of group 1 were received standard 
  food and water without any changes in their nutritional condition. Rats of group 
  2 were received EDTA at the dose of 40 mg kg<SUP>-1</SUP> as promotor of DMH 
  twice a week for 2 weeks. Rats of group 3 were received DMH at the dose of 40 
  mg kg<SUP>-1</SUP> twice a week for 2 weeks for induction the cancer. The rats 
  of groups 4 and 5 after induction of cancer were received resveratrol at the 
  dose of 10 and 20 mg/kg/day for 10 weeks orally, respectively. The 12 weeks 
  after treatment with resveratrol, animals were constrained and anesthetized 
  by xylazine and ketamine intraperitoneally. Then, segments of colon were sampled 
  for histopathological assessments. Immunohistochemical evaluations showed that 
  rate of the expression of &#946;-catenin proteins in treatment groups was less 
  than control group and there is a statistical significance among groups (p&lt;0.01).
ER  -