TY  - JOUR
T1  - Useful g.70014208G&gt;A SNP Marker in <i>MYBPC1</i> Gene Showing Marbling-Associated Expression Changes
AU - Yamada, Takahisa AU - Tong, Bin AU - Sasaki, Seiki AU - Muramatsu, Youji AU - Ohta, Takeshi AU - Kose, Hiroyuki AU - Yamashiro, Hideaki 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 23
SP  - 4446
EP  - 4450
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.4446.4450
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.4446.4450
KW  - Allelic distribution
KW  -close marker
KW  -marbling
KW  -MYBPC1
KW  -single nucleotide polymorphism
AB  - Marbling, defined by the amount and distribution of intramuscular 
  fat is an economically important trait of beef cattle in Japan. Researchers 
  have earlier showed that the Myosin Binding Protein C, slow type (<I>MYBPC1</I>) 
  gene, known to interact with muscle protein including myosin, actin and titin 
  to regulate muscle contraction and to express in slow-twitch oxidative fiber 
  that is observed in high-marbled muscle and involved in development and maintenance 
  of the fiber, possesses expression differences in musculus longissimus muscle 
  between low-marbled Holstein and high-marbled Japanese Black steer groups. In 
  the present study, researchers found that a marker (DIK4787) close to the MYBPC1 
  was polymorphic between low-marbled Holstein and high-marbled Japanese Black 
  steer groups and exhibited significantly different allelic distribution between 
  Japanese Black sires with extremely high predicted breeding value for marbling 
  and with extremely low one. Further, researchers detected 3 Single Nucleotide 
  Polymorphisms (SNPs) in the promoter region of the <I>MYBPC1</I> gene between 
  low-marbled Holstein and high-marbled Japanese Black steer groups. A SNP in 
  the upstream of the promoter of the MYBPC1, referred to as g.70014208G&gt;A, 
  exhibited significantly different allelic distribution between animals with 
  extremely high predicted breeding value for marbling and with extremely low 
  one (p = 0.046). The other 2 SNPs seemed not to segregate in Japanese Black 
  beef cattle. The findings suggest that the g.70014208G&gt;A SNP may be related 
  to changes in <I>MYBPC1</I> gene expression and/or marbling. The g.70014208G&gt;A 
  SNP marker may be useful for effective marker-assisted selection to increase 
  the levels of marbling.
ER  -