TY  - JOUR
T1  - Polymorphisms in Promoter Regions of <I>MYH1</I> and <I>IRS1</I> Genes Showing Marbling-Associated Expression Changes
AU - Yamada, Takahisa AU - Tong, Bin AU - Sasaki, Seiki AU - Muramatsu, Youji AU - Ohta, Takeshi AU - Kose, Hiroyuki AU - Yamashiro, Hideaki 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 23
SP  - 4441
EP  - 4445
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.4441.4445
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.4441.4445
KW  - Allelic distribution
KW  -gene expression
KW  -IRS1
KW  -marbling
KW  -MYH1
KW  -single nucleotide polymorphism
AB  - Marbling, defined by the amount and distribution of intramuscular 
  fat is an economically important trait of beef cattle in Japan. Previously, 
  researchers have found that the Myosin Heavy Chain 1 (<I>MYH1</I>) gene coding 
  for an isoform of myosin heavy chain a major contractile protein which converts 
  chemical energy into mechanical energy in muscle which is expressed in slow-twitch 
  oxidative fiber and involved in development of the fiber and Insulin Receptor 
  Substrate 1 (<I>IRS1</I>) gene encoding a signaling adaptor protein which is 
  phosphorylated by insulin receptor and associated with insulin resistance and 
  birth weight, possess expression differences in musculus longissimus muscle 
  between low-marbled and high-marbled steer groups. In the present study, researchers 
  detected Single Nucleotide Polymorphisms (SNPs), g.29850738G&gt;A and g.120947716T&gt;C 
  in the promoter regions of the <I>MYH1 </I>and <I>IRS1</I> genes, respectively 
  between the 2 steer groups. However, the allelic distributions of the 2 SNPs 
  were indistinguishable between Japanese Black sires with extremely high predicted 
  breeding value for marbling and with extremely low one. An unknown SNP in the 
  distal region upstream of ~4 kb proximal promoter regions of the <I>MYH1</I> 
  and <I>IRS1</I> genes might be related to changes in gene expression and/or 
  marbling.
ER  -