TY  - JOUR
T1  - The Therapeutic Effect of Autogenic Adipose Derived Stem Cells Combined with Autogenic Platelet Rich Plasma in Tendons Disorders in Horses <I>in vitro</I> and <I>in vivo </I>Research
AU - Toker, Nezir Yasar AU - Wrzeszcz, Karol AU - Grzesiak, Jakub AU - Marycz, Krzysztof AU - Golonka, Pawel 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 23
SP  - 4324
EP  - 4331
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.4324.4331
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.4324.4331
KW  - adipose-derived mesenchymal stem
KW  -tissue regeneration
KW  -novel
KW  -Tendons
KW  -ultrasound
AB  - Naturally, occurring tendons injuries including superficial 
  digital flexor tendinopathy are the most frequent musculoskeletal disorders 
  in performance horses. Conventional methods of treatment with non steroidal 
  and steroidal anti-inflammatory medicaments in majority of cases lead to scar 
  formation, reducing the quality and efficiency of tissue regeneration. Novel 
  approach is aimed to use cells naturally present in an organism as regeneration 
  enhancing factor. In conducted research, the intralesional injections of autologous 
  adipose derived stem cells combined with autologous platelet concentrate therapeutic 
  potential was investigated in horses with 8-12 weeks duration superficial digital 
  flexor injury with severe scaring. Collected by clinical examinations data showed 
  positive effects of autologous, adipose-derived mesenchymal stem cells combined 
  with autologous platelet rich plasma injections on regeneration processes in 
  the course of superficial flexor tendon injures in horses. On the basis of ultrasound 
  examination, it was proved that the quality of healed tissue was significantly 
  higher in experimental group, comparing to control group. Obtained results confirmed 
  the beneficial pro-regeneration effects of stem cells/platelet concentrate combined 
  injections. The obtained data may also serve as valuable source of information 
  about morphology and behaviour of fat stem cells in culture or platelets appearance.
ER  -