TY  - JOUR
T1  - Genetic Variation at the TVB Locus in Chinese Native Chicken Breeds
AU - Ning, Z.H. AU - Yu, J.C. AU - Bao, M. 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 22
SP  - 4226
EP  - 4229
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.4226.4229
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.4226.4229
KW  - Genetic variation
KW  -tumor virus locus B
KW  -Chinese native chicken
KW  -anti-avian leukosis virus breeding
KW  -homozygous
AB  - Tumor Virus locus B (TVB) encodes the cellular receptor for 
  ALV subgroups B, D and E. Two Single Nucleotide Polymorphisms (SNPs) at nucleotide 
  positions 172 (C/T) and 184 (T/A) together differentiate the allelic transcripts 
  for TVB*S1, TVB*S3 and TVB*R. Genetic diversity at the TVB locus of chickens 
  was investigated in Chinese indigenous chickens and the White Leghorns. An earlier 
  undescribed nucleotide substitution at 184 (G to T) has been identified in Chinese 
  native chicken breeds using the direct sequencing. Researchers found that the 
  novel allele TVB*S´ was in all of Chinese native breeds but TC and homozygous 
  TVB*S'/*S' genotype found in ZZG, XSBNG and CHC, theirs frequencies were 0.28, 
  0.26 and 0.57, respectively. Except CHC, Chinese native chicken breeds have 
  higher homozygous TVB*S1/*S1 frequency than WL populations. The resistant allele 
  TVB*R was found in WL populations and TC flocks with a frequency of 0.44 and 
  0.11, respectively.
ER  -