TY  - JOUR
T1  - The Effect of Green Tea (<I>Camellia sinensis</I>) Extract on Liver Tissue Injury Consequent Isoniazid Administration in the Rats
AU - Mohajeri, Daryoush AU - Kaffash Elahi, Ramin 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 22
SP  - 4094
EP  - 4101
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.4094.4101
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.4094.4101
KW  - hepatoprotective activity
KW  -Isoniazid
KW  -hepatotoxicity
KW  -green tea extract
KW  -rats
AB  - Tuberculosis continues to be a common health problem worldwide. 
  Isoniazid, an antibiotic used routinely for tuberculosis chemotherapy is documented 
  to be a potent hepatotoxicant. The aim of the present study was to assess the 
  hepatoprotective activity of green tea (<I>Camellia sinensis</I>) extract (GTE) 
  against isoniazid induced hepatotoxicity in the rats. Male Wistar rats were 
  randomly allocated into 4 groups of 10 animals each including: normal healthy 
  control rats, healthy rats receiving GTE, toxicant control and toxicant drug 
  plus GTE treatment group. In groups 2 and 4 GTE (1.5%, w/v) was given as only 
  source of drinking for 8 weeks. In the midst stage of experiment (4th and 5th 
  weeks), Isonizid (50 mg kg<SUP>-1</SUP> b.w./day, i.p.) was administrated for 
  groups 3 and 4 for a period of 2 weeks. At the end of experiment, serum biomarkers 
  of liver tissue injury and product of lipid peroxidation (MDA), activities of 
  Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPX) and 
  Glutathione Reductase (GR) were assayed in liver homogenates. Finally, the biochemical 
  findings were matched with histopathological verifications. Significant differences 
  among the groups were determined by one-way analysis of variance followed by 
  Tukey post-test. In group 4, GTE significantly (p&lt;0.05) decreased the elevated 
  levels of serum biomarkers of hepatic injury and total bilirubin and significantly 
  (p&lt;0.05) increased the reduced levels of serum albumin and total proteins 
  (respectively p = 0.001, p = 0.032). In this group, GTE significantly (p&lt;0.05) 
  decreased the lipid peroxidation and elevated the decreased values of hepatic 
  antioxidants. Histopathologically, the changes were in the same direction with 
  biochemical findings. This study showed that the hepatoprotective effect of 
  GTE in isoniazid-induced oxidative damage may be related to its antioxidant 
  and free radical scavenging activity.
ER  -