TY  - JOUR
T1  - Mast Cell Morphological Heterogeneity: An Indicator of Skin Immune System Activation in Horses Affected with Summer Eczema
AU - Toker, Nezir Yasar AU - Chroszcz, Aleksander AU - Janeczek, Maciej AU - Grzesiak, J. AU - Moll, Eberhard AU - Czogala, J. AU - Marycz, K. 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 21
SP  - 4045
EP  - 4050
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.4045.4050
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.4045.4050
KW  - allergy
KW  -degranulation
KW  -mastocyte
KW  -equine
KW  -Sweet itch
AB  - Thirteen, 7 months old thoroughbred horses with no clinical signs of insect bite hypersensitivity, commonly exposed to culicoides bites were studied. Allergic individuals were determined by a positive intradermal skin test, performed with culicoides allergen. Animals with negative skin test served as a control. In horses serum levels of IgG were examined. From horses with positive skin test results, skin biopsies were examined by means of light and electron microscopy. Positive reaction against culicoides allergens confirmed that IgG even in absence of IgE can mediate allergic response in <1 year old horses. Ultrastructural skin studies showed marked activation within mast cells population in allergic horses even though they exhibited no clinical symptoms of summer eczema. There was marked domination of piece meal type of degranulation observed which indicated persistent inflammatory process within skin of asymptomatic animals. Moreover, skin mast cells of allergic horses whose IgG serum levels were relatively high besides piece meal often manifested anaphylactic and mixed type of degranulation.
ER  -