TY  - JOUR
T1  - Blinded Brushing Technique as a Novel Method to Inflict Injury on Rabbit Tracheal Airway Epithelium Structure
AU - H. Yahaya, Badrul AU - Z. Latahir, Ahmad 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 20
SP  - 3772
EP  - 3775
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.3772.3775
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.3772.3775
KW  - Blinded brushing technique
KW  -trachea
KW  -inflicted injury
KW  -cellular response
KW  -length of injury
AB  - The normal response on the airway epithelial lining given 
  injury comprises migration, proliferation and redifferentiation. Researchers 
  reported here a novel brushing technique for inflicting injury on the tracheal 
  airway, termed blinded brushing technique using rabbits as a model. Rabbits 
  were categorised as either treated with blinded-tracheal brushing or untreated 
  as to serve as control for normal tracheal epithelium structure. Researchers 
  subsequently euthanized all rabbits in different time points (ranges from for 
  30 min and 1, 6, 12 and 24 h) post-infliction in order to examine the effect 
  of the brushing to the tracheal epithelium structure. The results demonstrated 
  that this technique was successfully removed the intact epithelium layer and 
  its basement membrane without prior knowledge of location and position of the 
  target site on the tracheal epithelium. The length of the induced-injuries were 
  measured between the edges of the remaining epithelium bordering the lesion 
  and the length of the injured areas were gradually decreased over the time points 
  as compared to 30 min following injury. The decreases of the length of the injuries 
  indicate that regeneration process was activated as to restore the normal epithelium 
  layer. As conclusion, researchers had successfully developed a more practical 
  and time-efficient brushing technique that could be very useful technique as 
  to provoke cellular and molecular activations during airway regeneration and 
  repair in respond to injury.
ER  -