TY  - JOUR
T1  - Endothelin in Bronchial Biopsy Specimens from Horses with Recurrent Airway Obstruction
AU - Fulvio, Laus AU - Emanuele, Paggi AU - Francesca, Mariotti AU - Matteo, Cerquetella AU - Stefano, Sgariglia AU - Beniamino, Tesei 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 19
SP  - 3647
EP  - 3651
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.3647.3651
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.3647.3651
KW  - Horse
KW  -recurrent airway obstruction
KW  -endothelin
KW  -biopsy
KW  -immunohistochemical analysis
AB  - Recurrent Airway Obstruction (RAO) is a chronic, worldwide recognized diseases of horses. Despite the well known clinical presentation and the ease of diagnosis, the exact etiology and pathogenesis are still unclear which makes it difficult prevention and treatment. Recurrent obstruction of airway is caused by mucus production, bronchospasm and bronchial edema and the most important clinical signs are chronic cough and expiratory effort. The ET-1 is the most potent vasoconstrictor molecule up to now identified, produced by several cells as endothelial cells, smooth muscle cells and epithelial cells of airways. The ET-1 is a potent proinflammatory, secretagogues and bronchoconstrictors mediator. ET-1 can cause bronchial contraction on bronchial rings of horses <I>in vitro</I>, especially in horse with respiratory disease.
ER  -