TY  - JOUR
T1  - VEGF/VEGFR-2 mRNA Expression in a Mouse Menstrual-Like Model by Pharmacologic Progesterone Withdrawal
AU - Xu, Xiangbo AU - He, Bin 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 19
SP  - 3512
EP  - 3516
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.3512.3516
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.3512.3516
KW  - Vascular Endothelial Growth Factor (VEGF)
KW  -Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)
KW  -mouse menstrual-like model
KW  -pharmacologic progesterone withdrawal
KW  -epithelium
AB  - Vascular Endothelial Growth Factor (VEGF)/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) are vital in menstruation. This study aimed to explore their expressions in a mouse menstrual-like model by pharmacologic progesterone withdrawal. A mouse model was prepared by administration of mifepristone after decidualization of ovariectomized mice. Semiquantive-PCR and <I>in situ</I> hybridization were performed to the expression patterns of VEGF/VEGFR-2 mRNA. VEGF mRNA peaked at 24 h and obviously reduced at other time points. VEGF mRNA was mainly located in the basal zone from 0-24 h, epithelium and stroma zone from 32-48 h. VEGFR-2 mRNA was higher at 0 and 40 h rather weak at 8, 16 and 32 h, nearly not expressed at 24 and 40 h. VEGFR-2 mRNA was strongly located in the basal zone at 0, 8 and 16 h in the epithelium zone at 24, 32 and 48 h and epithelium and stroma zone at 40 h. The locations of VEGF/VEGFR-2 in mouse menstrual-like model displayed regional character.
ER  -