TY  - JOUR
T1  - Construction and Immunogenicity Study of a Veterinary Recombinant Influenza A (H1N1) Inactivated Vaccine
AU - Liao, Ming AU - Jia, Weixin AU - Qi, Wenbao AU - Gong, Lang AU - Sun, Mingming 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 17
SP  - 3213
EP  - 3216
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.3213.3216
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.3213.3216
KW  - Influenza A (H1N1) virus
KW  -veterinary inactivated vaccine
KW  -recombinant
KW  -PR8 strain
KW  -immunity
AB  - The recombinant virus with human H1N1 influenza virus HA, 
  <I>NA</I> gene fragments and six gene fragments of the PR8 strain was successfully 
  rescued and prepared in an recombinant (H1N1) influenza inactivated vaccine 
  as an antigen. Researchers chose BALB/c mice as animal models to evaluate the 
  vaccine&#146;s immunity. The HI test 
  results show that the vaccine can induce a high level HI antibody for human 
  influenza A virus (H1N1) and swine influenza virus (H1N1) in mice. The HI antibody 
  can be induced 1 week after immunization. Researchers monitored for 8 weeks 
  after the second immunization and high antibody levels remained. The mouse challenge 
  protection test showed that the vaccine can effectively protect the attack of 
  the human influenza A (H1N1) and swine influenza virus (H1N1). It provides technical 
  reserves for preventing a pandemic H1N1 influenza in the future in swine or 
  other mammals.
ER  -