TY  - JOUR
T1  - Extracorporeal Shock Wave Therapy Improves the Impaired Neovascularization in Diabetic Wound Healing via Altering the Expression of Angiopoietin-1 and Angiopoietin-2
AU - Yan, Xiaoyu AU - Yang, Guang AU - Cheng, Xiangguo AU - Liang, Cheng AU - Chai, Yimin AU - Luo, Congfeng AU - Zeng, Bingfang 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 17
SP  - 3160
EP  - 3168
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.3160.3168
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.3160.3168
KW  - Diabetes
KW  -wound healing
KW  -neovascularisation
KW  -angiogenesis
KW  -extracorporeal shock wave therapy
KW  -angiopoietins
AB  - The present research is to observe the effect of Extracorporeal 
  Shock Wave Therapy (ESWT) on neovascularisation and expression of Ang-1, Ang-2 
  and VEGF in promoting excisional wound healing in diabetic rat model. Excisional 
  wounds were made in STZ-induced diabetic rats and randomly divided into treatment, 
  diabetic control and normal control groups. Wound in treatment group was treated 
  by ESWT with 0.11 mJ/mm<sup>2</sup>, 1.5 Hz and 500 pulses 1 day post-wounding. 
  In diabetic and normal control groups, wound received no ESWT. Wound closing 
  rate and healing time were calculated. Granulation tissue, neovascularization 
  and expression of Ang-1, Ang-2 and VEGF in wound tissue from different groups 
  were compared. The results showed that healing of diabetic wound was poor and 
  expressions of angiopoietin-1, angiopoietin-2 and VEGF were altered as compared 
  with normal wound. After ESWT however, microvessels and granulation tissue were 
  increased and the expressions of VEGF and Ang-1 were increased while Ang-2 expression 
  was decreased, respectively. In conclusion, abnormal expression of Ang-1, Ang-2 
  and VEGF may contribute to poor neovascularization and impaired healing in the 
  diabetic wound and topical ESWT application can improve diabetic wound healing 
  by enhancing neovascularisation and altering the expression of Ang-1, Ang-2 
  and VEGF. ESWT may represent a feasible method for improving the impaired healing 
  of diabetic wound.
ER  -