TY  - JOUR
T1  - Progesterone Promotes HOXa-10 Expression in Mouse During Embryo Implantation Period
AU - Zhao, Shuhong AU - Wu, Di AU - Li, Guanglei AU - Lin, Ruiyi AU - Li, Changchun 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 17
SP  - 3076
EP  - 3080
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.3076.3080
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.3076.3080
KW  - HOXa-10
KW  -Progesterone (P4)
KW  -QPCR
KW  -mouse
KW  -injection
AB  - <i>HOXa-10</i> (HomeoboxA10) gene plays an important role 
  in embryo implantation and development regulated by Progesterone (P4) which 
  is secreted mainly through corpus luteum cells to regulate the embryo development. 
  The study mainly investigated the effect of progesterone on the expression of 
  HOXa-10 in the endometrium during the embryo implantation. Kunming mice were 
  injected progesterone (2 or 4 mg/each per day), respectively from early pregnant 
  D1 (the 1st day of pregnancy) to D4 (the 4th day of pregnancy) or D6 (the 6th 
  day of pregnancy) by intraperitoneal injection. The endometrium samples of early 
  pregnant D4, D5 (the 5th day of pregnance) and D6, from 3 groups were collected 
  with each group containing 3 mice. Real-time fluorescence Quantitative PCR (QPCR) 
  was used to analyze the expression of the mouse <i>HOXa-10</i> gene. The result 
  demonstrated that the expression level of HOXa-10 was increased at pregnant 
  D4 and there was a peak at pregnant D5 then it began to decrease at pregnant 
  D6. Besides, the expression level of HOXa-10 was dependent on the dose of progesterone.
ER  -