TY  - JOUR
T1  - Effect of 4-Nitrophenol on Male Mice Reproductive Function
AU - Wang, Xian-Zhong AU - Lin, Ying AU - Wang, Rong-Feng AU - Wang, Rui-Jing AU - Wang, Xiao-Yi AU - Yang, Bo-Wen 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 15
SP  - 2677
EP  - 2682
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.2677.2682
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.2677.2682
KW  - Adult male mice
KW  -4-Nitro phenol
KW  -testes
KW  -reproductive function
KW  -spermatogenesis
KW  -biological indicators
AB  - 4-Nitrophenol (PNP) has deleterious effects on mammalian physiological 
  functions. The objective of the study is to identify the effect of 4-Nitrophenol 
  on male mice reproductive function. About 50 adult Kunming male mice (25-30 
  g) were randomly divided into 5 groups, administrated (0.1, 10 and 100 mg kgwt<sup>-1</sup>) 
  orally for 35 days. Semen quality, histological structure of testis and ultrastructure 
  of primary spermatocytes were detected to analysis effect of PNP on the spermatogenesis 
  function. Furthermore, the functions of liver and kidney were determined by 
  testing the blood of biological indicators. The results showed that 0.1 mg kgwt<sup>-1</sup> 
  PNP decreased slightly in body weight (p&gt;0.05) but significantly reduced 
  and rogen hormone-sensitive organ weights (p&lt;0.05). However, semen quality 
  (total sperm count, survival, linear motion and acrosome integrity rate), liver 
  function (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, 
  total protein and plasma albumin (p&gt;0.05) and renal function (urea, uric 
  acid and creatinine) had no significant changes (p&gt;0.05); 10 and 100 mg kgwt<sup>-1</sup> 
  PNP reduced not only significantly body weight, androgen hormone-sensitive organ 
  weights (p&lt;0.05) but also significantly reduced semen quality, liver and 
  renal function and the effect of 100 mg kgwt<sup>-1</sup> PNP was stronger than 
  that of 10 mg kgwt <sup>-1</sup> PNP (p&lt;0.05); three doses of PNP on the 
  testicular structure and ultra structure of primary spermatocytes had injury 
  effect. With increasing concentrations of PNP, the damage was enhanced. About 
  100 mg kgwt<sup>-1</sup> PNP significantly disrupted testicular structure and 
  ultra structure of the primary spermatocytes. This shows that PNP affects the 
  liver and kidney detoxification function which reduced the detoxification ability 
  of body and damages the process of spermatogenesis.
ER  -