TY  - JOUR
T1  - Protective Effects of Vitamin E and Vitamin C on Gentamicin-Induced Nephrotoxicity in Sheep
AU - Mashayekhi, Mohammad AU - Valilou, Mohammad Reza 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 15
SP  - 2618
EP  - 2622
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.2618.2622
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.2618.2622
KW  - Vitamin E and C
KW  -gentamicin
KW  -nephrotoxicity
KW  -sheep
KW  -antioxidant vitamins
KW  -Iran
AB  - Gentamicin is a commonly used antibiotic medication and this 
  is an aminoglycoside antibiotic, used to treat many types of bacterial infections, 
  particularly those caused by gram-negative organisms. Gentamicin can also be 
  highly nephrotoxic, particularly if multiple doses accumulate over a course 
  of treatment or in dehydrated cases. The aim of this study was to investigate 
  the protective role of vitamin E against Gentamicin-induced nephrotoxicity in 
  sheep. Eighteen healthy Ghezel sheep were randomly divided into three groups 
  of control and treatments with vitamin C and E. All sheep of two groups were 
  received 20 mg/kg/body wt. of Gentamicin every 8 h by intramuscular injection 
  for 10 days. Treatment group were also receive 250 mg/kg/body wt. of vitamin 
  E and C daily by intramuscular injection for 14 days. This study revealed that 
  the GM-induced renal toxicity as measured by multiple functional, structural 
  and enzymatic factors is significantly reduced by co-supplementation of vitamins 
  C and E. The results of this study suggest the potential of antioxidant vitamins 
  to protect against GM-induced nephrotoxicity.
ER  -