TY  - JOUR
T1  - Angiogenic and Osteogenic Responses Related to Femoral Neck Fractures Treated at Different Fracture-To-Surgery Intervals in a Canine Model
AU - Zhang, C.Q. AU - Gao, Y.S. AU - Ding, H. AU - Yu, X.W. 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 15
SP  - 2611
EP  - 2617
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.2611.2617
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.2611.2617
KW  - Femoral neck fractures
KW  -angiogenesis
KW  -osteogenesis
KW  -Canine Model
KW  -dogs
KW  -China
AB  - The aim of current prospective study was to investigate systemic 
  changes in angiogenic factor VEGF and osteogenic factor IGF-1 and the local 
  expression of BMP-2 and Runx-2 in femoral neck fractures of canines that were 
  treated at different fracture-to-surgery intervals. About 24 dogs had surgically 
  induced femoral neck fractures which were divided randomly and equally into 
  three groups. In group A, the fractures were reduced and stabilized by paralleled 
  pins immediately while they were managed 3 days later in group B and 3 weeks 
  later in group C. Pre and post-operative peripheral serum was prepared for detection 
  of systemic concentrations of VEGF and IGF-1 via ELISA Method. Postoperative 
  radiological and histological examinations were employed to observe fracture 
  union and occurrence of Osteonecrosis of the Femoral Head (ONFH). Local expressions 
  of BMP-2 and Runx-2 were detected via immunohistochemical staining. Another 
  2 dogs had fractures untreated for negative control. Systemic changes in VEGF 
  and IGF-1 were shown to share similarities when fractures were treated at different 
  fracture-to-surgery intervals or left untreated. Moreover, the local expression 
  of BMP-2 and Runx-2 were not statistically different in all treated and untreated 
  animals. The manner of the response of systemic expression of VEGF and IGF-1 
  and local expression of BMP-2 and Runx-2 showed great similarity when femoral 
  neck fractures were treated at different fracture-to-surgery intervals. Angiogenic 
  and osteogenic responses might not be responsible for fracture-induced ONFH.
ER  -