TY  - JOUR
T1  - Effects of <I>Androctonus crassicauda</I> Scorpion Venom on the Heart Tissue
AU - Bakir, Fatih AU - Ozkan, Ozcan AU - Eray Alcigir, Mehmet AU - Atalay Vural, Sevil 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 14
SP  - 2594
EP  - 2599
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.2594.2599
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.2594.2599
KW  - Scorpion
KW  -Androctonus crassicauda
KW  -venom
KW  -heart
KW  -cardiac troponin I
AB  - The aim of this research was to determine the presence of cardiac injury in rabbit animal model with envenomed <I>Androctonus crassicauda</I> venom by serial measurements of cardiac troponin I and assessed the histopathologic changes of the heart for evaluation of the extent of damages. Experimental envenomations were performed by intravenous of 0.5 mL of PSS containing a scorpion venom. Blood samples were collected from each animal (0 min [control]) before envenomation. Blood samples were collected from each animal on the 1st, 3rd, 6th and 24th h after venom injection. Serum cardiac troponin I level determined using abbot architect troponin I kit (Abbott Laboratories, USA). Cardiac tissues taken from envenomed animals were for histopathological examination after 24 h. The scorpion venom led to significantly increased in serum cardiac troponin I enzyme activities at the 3rd, 6th and 24th h after injection when compared with those of the control group. <I>In vivo</I> effects of the venom observed such as salivation, lacrimation, deep dyspnea and tachypnea in rabbits. Histopathological examination of heart tissue was showed development of myocardial injury. This study demonstrated that <I>Androctonus crassicauda</I> venom may be cause development of myocardial injury. The using of cardiac troponin I as a follow-up criterion in the scorpion envenoming may be allow early establishing of the cardiac involvement.
ER  -