TY  - JOUR
T1  - Toxicokinetics of T-2 Toxin, HT-2 Toxin and T-2 Triol after Intravenously Administrated T-2 Toxin in Swine
AU - Sun, Yong-Xue AU - Zhao, Hai-Yan AU - Liu, Yu-Jing AU - Dai, Zhen-Qing AU - Fang, Bing-Hu 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 12
SP  - 1977
EP  - 1981
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.1977.1981
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.1977.1981
KW  - Toxicokinetics
KW  -T-2 toxin
KW  -metabolites
KW  -swine
KW  -blood
KW  -parameters
AB  - Toxicokinetics of trichothecene mycotoxin, T-2 toxin, HT-2 toxin and T-2 triol were determined in seven swine, after intravenous administration (i.v.) of T-2 toxin (0.5 mg kg<SUP>-1</SUP>). The T-2 toxin, HT-2 toxin and T-2 triol plasma concentrations were analyzed by HLPC-MS/MS from 2.5 min to 6 h. The mean pharmacokinetic parameters for T-2 toxin, HT-2 toxin and T-2 triol were respectively: half-life (t<SUB>1/2&#955;Z</SUB>) 11.7, 37.7 and 25.6 min; areas under the plasma concentration-time curves (AUC<SUB>0-00</SUB>): 16499, 4619 and 11011 min ng mL<SUP>-1</SUP>. Following i.v administration, times to observed maximal concentration (Tmax) were 2.5, 2.5 and 7.5 min, respectively. No T-2 tetraol was detected at all sampling times. The total body Clearance (Cl) and the apparent steady-state volumes of distribution (V<SUB>ss</SUB>) for T-2 toxin were 0.662 L kg<SUP>-1</SUP> and 0.038 L/min/kg. This study demonstrated that T-2 toxin is rapidly removed from the blood followed by its fast conversion to metabolites.
ER  -