TY  - JOUR
T1  - Polymorphism in Promoter Region of <I>CDC10</I> Gene Showing Marbling-Associated 
  Expression Changes
AU - Yamada, Takahisa AU - Kose, Hiroyuki AU - Tanomura, Hideki AU - Yamamoto, Takuji AU - Tong, Bin AU - Muramatsu, Youji AU - Ohta, Takeshi AU - Sugiyama, Toshie 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 11
SP  - 1930
EP  - 1933
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.1930.1933
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.1930.1933
KW  - Allelic distribution
KW  -CDC10
KW  -close marker
KW  -marbling
KW  -single nucleotide polymorphism
AB  - Researchers have previously showed that the septin 7 (<I>CDC10</I>) gene involved in cellular proliferation possesses expression differences in musculus longissimus muscle between low-marbled Holstein and high-marbled Japanese Black steer groups. In the present study, researchers found that a marker (BM6437) close to the CDC10 was polymorphic between low-marbled Holstein and high-marbled Japanese Black steer groups and exhibited significantly different allelic distribution between Japanese Black sires with extremely high predicted breeding value for marbling and with extremely low one. Further, researchers detected Single Nucleotide Polymorphism (SNP) in the promoter region of the <I>CDC10</I> gene between low-marbled Holstein and high-marbled Japanese Black steer groups. The allelic distribution of the SNP, referred to as g.63629097G&gt;C in the CDC10 was indistinguishable between Japanese Black sires with extremely high predicted breeding value for marbling and with extremely low one. The findings suggest that an unidentified true causal mutation which is in linkage disequilibrium with the BM6437 marker but not the g.63629097G&gt;C SNP may be related to changes in <I>CDC10</I> gene expression and/or marbling.
ER  -