TY  - JOUR
T1  - Identification, Cloning, Expression of a Novel Functional <I>Anas platyrhynchos</I> mRNA TLR4
AU - Wang, Yu AU - Yang, Yongjun AU - Liu, Shanshan AU - Lei, Liancheng AU - Ma, Jisheng AU - Li, Xiaokun AU - Han, Wenyu AU - Sun, Changjiang AU - Abouelmaatti, Reham R. AU - Elfeil, Wael K. AU - Mandour, Mostafa AU - Fawzy, Mohamed AU - Shalaby, Mohamed N. 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 10
SP  - 1727
EP  - 1733
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.1727.1733
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.1727.1733
KW  - Anseriformes
KW  -Avian
KW  -duck-toll like receptor
KW  -TLR4
KW  -gene expression
KW  -China
AB  - Toll like receptor mediate immune response through recognition of Pathogen-Associated Molecular Patterns (PAMPs) thus play important roles in host defense. Little is known about the Avian Immune System structure and the majority of it based on chicken as a Universal Avian Model while recent researches showed that a lot of factor not common between chicken and other birds. This research aimed to identify and clone the duck TLR4 as a model to Anseriformes species, researchers success to clone a novel functional dTLR4 mRNA and deposit into the NCBI GenBank database where the mRNA consist of 2529 nucleotide and it showed 81% identity with chicken and 78% identity with zebra finch while showed 95% identity with goose. The translated amino acid showed that the gene consist of 843 amino acid and the transmembrane structure analysis reveal a novel unique LRR motifs in duck and absent in both chicken and zebra finch at the position 56-80 also showed that TIR domain consist of 146 amino acid not 145 like chicken and zebra finch.
ER  -