TY  - JOUR
T1  - Inhibition of Postprandial Hyperglycemia Prevents the Incidence of Diabetes in Spontaneously Diabetic Torii (SDT) Rats
AU - Ohta, Takeshi AU - Miyajima, Katsuhiro AU - Shinohara, Masami AU - Yamamoto, Takuji AU - Yamada, Takahisa 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 10
SP  - 1583
EP  - 1587
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.1583.1587
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.1583.1587
KW  - diabetes
KW  -insulin
KW  -SDT rat
KW  -postprandial hyperglycemia
KW  -Pancreas
KW  -dose
AB  - The Spontaneously Diabetic Torii (SDT) rat shows Impaired Glucose Tolerance (IGT) before the onset of diabetes. The present study investigated the effects of an improvement of IGT on the incidence of diabetes in male SDT rats. Voglibose, &#945;-glucosidase inhibitor was used to improve glucose intolerance. In SDT rats at 10 weeks of age, a single dose of voglibose (0.03, 0.1 and 0.3 mg kg<SUP>-1</SUP>) improved the glucose tolerance dose-dependently. Moreover, voglibose was administered as a dietary mixture to SDT rats from 10-20 weeks of age. As a result, voglibose suppressed the incidence of diabetes in SDT rats. In voglibose-treated rats at 20 weeks of age, pancreatic weights were increased and the histopathological pancreatic changes such as irregular boundaries, atrophy, fibrosis and decrease of insulin-immunoreactivity in islets were improved. In conclusion, inhibition of postprandial hyperglycemia prevented the incidence of diabetes in SDT rats. Also, SDT rat is a useful model for development of a preventive drug on diabetes.
ER  -