TY  - JOUR
T1  - The MHC class I of Grass Carp (<I>Ctenopharyngodon idellus</I>) With Different Way to Present Peptide
AU - Zhen-Hu, Jia 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 9
SP  - 1455
EP  - 1460
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.1455.1460
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.1455.1460
KW  - MHC I
KW  -tapasin
KW  -grass carp
KW  -peptide
KW  -assembly
KW  -China
AB  - Major Histocompatibility Complex class I (MHC class I) proteins are critical for immune defenses against viruses. Polygeny and polymorphism of alleles contribute to the breadth of the immune response. In previous study, researchers showed that a <I>MHC class I</I> gene termed Ctid-AB190929 was found from a grass carp. It was a expressed gene from cDNA library. Now, characterization of a genomic clone from the same grass carp constructed fosmid genome library allows us to further analysis the MHC class I region. This clone carried whole <I>MHC class I</I> and <I>tapasin</I> gene. This MHC class I termed Ctid-UBA0201 was the classical MHC class I by genomic analysis. But the amino acid sequences of Ctid-UBA0201 were differed from that of Ctid-AB190929. As lower vertebrates, appear to use a single expressed MHC class I locus to present a wide variety of peptide to antigen. The Ctid-UBA0201 could be the allelic gene of Ctid-AB190929. As the <I>tapasin</I> gene may be a unexpressed gene by genomic analysis, the Ctid-UBA0201 may present a wide variety of peptide without the <I>tapasin</I> gene to control the assembly. It may preserve genetic diversity which can be exchanged when the species face a new pathogen.
ER  -