TY  - JOUR
T1  - Pancreatic Abnormalities at a Young Age in Spontaneously Diabetic Torii (SDT) Rats
AU - , Takahisa Yamada AU - Ohta, Takeshi AU - Shinohara, Masami AU - , Takuji Yamamoto 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 9
SP  - 1322
EP  - 1326
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.1322.1326
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.1322.1326
KW  - HOMA
KW  -IGT
KW  -SDT rat
KW  -reduction
KW  -insulin content
KW  -pancreatic
AB  - The Spontaneously Diabetic Torii (SDT) rat is a non-obese diabetic model showing various metabolic abnormalities in pre-diabetic stage. In this study, researchers investigated the pancreatic function at young ages, 5 and 7 weeks. At 5 weeks, SDT rats showed glucose intolerance and reduction of Homeostasis Model Assessment (HOMA)-β. At 7 weeks, the insulin content in pancreas was also decreased. Insulinogenic index showed no change at 5 and 7 weeks of age. In conclusion, the pancreatic function in SDT rats was decreased from a young age after weaning and the rat is a useful Animal Model to examine the pathophysiological features of Impaired Glucose Tolerance (IGT).
ER  -