TY  - JOUR
T1  - Polymorphism of <I>BMP2</I> Gene Associated with Growth Traits in Guizhou Semi-Fine Wool Sheep
AU - , Xiao Yun Shen AU - Li, Li Juan AU - , Yong Jun Li AU - , Wen Ting Li AU - , Xin Wang 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 8
SP  - 1110
EP  - 1115
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.1110.1115
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.1110.1115
KW  - BMP-2 gene
KW  -Guizhou Semi-Fine Wool sheep
KW  -growth traits
KW  -body height
KW  -China
AB  - Bone Morphogenetic Protein 2 (BMP2) plays a crucial role in bone growth. The objective of this study was to investigate variations in sheep <I>BMP2</I> gene and their associations with growth traits in 320 Guizhou Semi-Fine Wool sheep. Five fragments of <I>BMP-2</I> gene were investigated only exon2 region of <I>BMP-2</I> gene showed polymorphism after PCR-SSCP and DNA sequencing methods. There was one G&gt;A (g. 273 G&gt;A) mutation located in nucleotide position of GenBank Accession No. EU854586 which constructed three genotypes (LL, LW and WW). The frequencies of allele L and genotype LL were dominant in Guizhou Semi-Fine Wool sheep. The PIC (Polymorphism Information Content) values of the Guizhou Semi-Fine Wool sheep were 0.3261 belong to median polymorphism. Associations between growth traits and <I>BMP2</I> gene polymorphism were investigated and significant statistical association results were found in body height, body length and chest circumference (p&lt;0.05). These results strongly suggested that the <I>BMP2</I> gene is a candidate gene that influences growth traits in Guizhou Semi-Fine Wool sheep. Further investigations are required for detecting the polymorphism of this gene in a broad variety of sheep breeds and populations.
ER  -