TY  - JOUR
T1  - Influence of Selenium on Hepatic Antioxidant Capacity in Ducklings Intoxicated with Afatoxin B<SUB>1</SUB>
AU - Guo, S.N. AU - Shi, D.Y. AU - Liao, S.Q. AU - Su, R.S. AU - Lin, R.Q. AU - Lin, Y.C. AU - Tang, Z.X. 
JO  - Journal of Animal and Veterinary Advances
VL  - 11
IS  - 7
SP  - 1052
EP  - 1055
PY  - 2012
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2012.1052.1055
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2012.1052.1055
KW  - Selenium
KW  -hepatic antioxidant capacity
KW  -afatoxin B1
KW  -activity
KW  -ducklings
KW  -dysfunction
AB  - To investigate the influence of selenium on hepatic antioxidant capacity in ducklings administrated with Afatoxin B<SUB>1</SUB> (AFB<SUB>1</SUB>), ninety 7 days old ducklings were randomly divided into three groups (groups I-III). Group I was used as a blank control. Group II was administered with AFB<SUB>1</SUB> (0.1 mg kg<SUP>-1</SUP> body weight). Group III was administered with AFB<SUB>1</SUB> (0.1 mg kg<SUP>-1</SUP> body weight) plus selenium (sodium selenite, 1 mg kg<SUP>-1</SUP> body weight). All treatments were given once daily for 21 days. The results showed that the activity of hepatic Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GSH-Px) and Glutathione Reductase (GR) in group II ducklings significantly decreased when compared with group I (p&lt;0.01). Furthermore, the content of hepatic Malondialdehyde (MDA) significantly increased (p&lt;0.01). However, the activities of hepatic SOD, CAT, GSH-Px and GR in group III ducklings significantly increased when compared with group II (p&lt;0.05). In addition, the content of hepatic MDA significantly decreased (p&lt;0.01). These results revealed that AFB<SUB>1</SUB> significantly induced hepatic antioxidant function dysfunction. However, selenium could significantly alleviat the negative effect induced by AFB<SUB>1</SUB>.
ER  -