TY  - JOUR
T1  - Molecular Investigation on DNA-PKcs Gene and Identification of SCID Carriers among Iranian Arabian HorsesUsing a Test Based on PCR
AU - Aliabad, Ali Javanrouh AU - Javanmard, Arash AU - Seyedabadi, Hamid Reza AU - Banabazi, Mohamad Hossein AU - Asadzadeh, Nader AU - Afraz, Fazlollah 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 7
SP  - 865
EP  - 867
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.865.867
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.865.867
KW  - carrier
KW  -genetic defect
KW  -Iranian arab horse
KW  -DNA-PKcs
KW  -SCID
KW  -preserve
AB  - Severe Combined Immunodeficiency Disease (SCID) is an autosomal recessive hereditary disease occurring among Arabian horses. The genetic defect responsible for this disease was recently identified as a 5-basepair deletion in the gene encoding DNA-Protein Kinase catalytic subunit (DNA-PKcs). Horses with one copy of the gene appear normal while horses with two copies of the gene manifest the disease. The only way to avoid the economic losses is early detection of SCID carriers. Because the real value of this test is that breeders can use it to ensure that they will never produce a SCID foal and that they can by breeding carriers to clears, preserve the unique and positive characteristics of exceptional carriers. And thereby breed out the undesirable gene over several generations.
ER  -