TY  - JOUR
T1  - Expression of Augmenter of Liver Regeneration and Nuclear Faction-κB in Human Hepatocellular Carcinoma
AU - Aimin, Zhang AU - Shiqiang, Shen 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 4
SP  - 480
EP  - 483
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.480.483
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.480.483
KW  - Augmenter of liver regeneration
KW  -China
KW  -partial role
KW  -clinicopathological
KW  -hepatocellular carcinoma
KW  -nuclear faction-ºB
AB  - To determine whether the levels of expression of the Augmenter of Liver Regeneration (ALR) and nuclear faction-κB(NF-κB) were assoiated with the clinicopathological features in human Hepatocellular Carcinoma (HCC). Gene expression was measured by using RT-PCR in the 30 human HCC tissues, matched adjacent tissues and 8 normal hepatic tissues. The clinicopathological data of all patients were also collected. Higher expression of ALR mRNA was observed in HCC tissues compared with normal liver tissue (p<0.05), it did not differ from the expression of matching non-neoplastic tissue in the same patient (p>0.05). Expression of both two genes were not found to be significantly associated with clinical/pathologic factors. (p>0.05). The expression of ALR mRNA in HCC tissues was positively correlated with NF-κB mRNA (r = 0.382, p<0.05). Up-regulation of ALR may play partial role of carcinogenesis through MAPK pathway in HCC.
ER  -