TY  - JOUR
T1  - Alterations in Growth Related Genes (<I>GH-I</I>, <I>IGF-I</I> and <I>IGF-II</I>) Expression with Acute Copper Exposure in Rainbow Trout
AU - Aksakal, Ercument AU - Ceyhun, Saltuk Bugrahan AU - Beydemir, Sukru AU - Erdogan, Orhan 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 25
SP  - 3334
EP  - 3339
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.3334.3339
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.3334.3339
KW  - Copper
KW  -growth hormone
KW  -insulin like growth factors
KW  -gene expression
KW  -multiplex real-time PCR
KW  -rainbow trout
AB  - In this study, the acute effects of copper (CuSO<SUB>4</SUB>.5H<SUB>2</SUB>O) on the expression of Growth Hormone-I (GH-I) and Insulin like Growth Factors I and II (IGF-I and IGF-II) were investigated in rainbow trout (<I>Oncorhynchus mykiss</I>) muscle tissue. For this purpose, rainbow trout were exposed to 100 &#956;g L<SUP>-1</SUP> (Sublethal concentration) copper sulfate in moderately hard freshwater. After 6, 12, 24 and 48 h of treatment, expression of white muscle GH-I, IGF-I and IGF-II mRNAs were measured by means of quantitative real-time PCR. During the exposure experiments, no mortalities occurred. All mRNA levels significantly decreased after copper administration (p&lt;0.05). The results indicate that short term copper exposure suppresses the mRNA expression levels of GH-I, IGF-I and IGF-II in rainbow trout muscles.
ER  -