TY  - JOUR
T1  - Resveratrol Inhibits MMP-2 Expression of Hepatoma in Nude Mice
AU - Chen, Xiaoping AU - Li, Deyu AU - Yu, Haibo 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 1
SP  - 33
EP  - 37
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.33.37
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.33.37
KW  - Resveratrol
KW  -hepatocellular carcinoma
KW  -invasion
KW  -matrix metalloproteinase-2
KW  -NF-kappa B
KW  -protein
AB  - Resveratrol (trans-3, 4&#146;, 5-trihydroxystilbene) is a natural phytoalexin found in grapes and other plants that has anti-cancer and anti-inflammatory effects. The aim of this study was to find that resveratrol suppresses matrix metalloproteinase-2(MMP-2) expression in hepatoma <I>in vivo</I>. Tumor volume and invasion ability of liver transplanted tumor in nude mice were observed. MMP-2 mRNA and protein of the tumor were investigated by RT-PCR and Western-blot. NF-kappa B activity was measured by EMSA. Growth of the transplanted tumor was obviously by resveratrol at 50 mg kg<SUP>-1</SUP> (p&lt;0.05) and 100 mg kg<SUP>-1</SUP> (p&lt;0.05). Liver metastasis of the tumor was inhibited by 100 mg kg<SUP>-1</SUP> resveratrol (p&lt;0.05). MMP-2 protein was down regulated due to decreased MMP-2 mRNA expression. NF-kappa B activity was also extensively inhibited by resveratrol at 50 and 100 mg kg<SUP>-1</SUP>. The results suggest that resveratrol may inhibit growth and invasion ability by down regulate MMP-2 expression of hepatoma in nude mice. This effect was regulated by NF-kappa B pathway.
ER  -