TY  - JOUR
T1  - The Effect of an Attenuated Rabies Virus SRV<SUB>9</SUB> on Suckling Mouse Growth After Intracerebral Inoculation
AU - Hu, Rongliang AU - Yuan, Ziguo AU - Ding, Zhuang AU - Zhang, Shoufeng AU - Sun, Chenglong AU - Jin, Yuzhu AU - Wang, Xiaohu 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 3
SP  - 322
EP  - 326
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.322.326
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.322.326
KW  - suckling mouse
KW  -vaccination
KW  -Rabies Virus (RV)
KW  -intracerebrally inoculation
KW  -growth
KW  -SRV9 strain
AB  - Rabies virus is a kind of virus having strict neurotropic property. Intracerebral inoculation method was commonly used to RV-related research. SRV<SUB>9</SUB> is an attenuated RV vaccine strain. In the present study, we inoculated intracerebrally on suckling mouse with SRV<SUB>9</SUB> strain. The results showed that SRV<SUB>9</SUB> could cause a mortality rate of 100% on suckling mice below 13 day old. The mortality rates of 14-17 day old mice were 68, 33, 33 and 17%, respectively without incidence above 18 day old. Meanwhile, the results showed that the growth of survival suckling mice was inhibited remarkably after intracerebral inoculation SRV<SUB>9</SUB>. The 16 day old survival suckling mice were chosen to perform body weight test and the result showed that the weight growth was very slow with 14% less than normal growth rate. However, 2 weeks latter the weight of the mice began to recover gradually but slowly. It was suggested that the intracerebral RV reproduction could take a significant effect on the growth and development of the mice and with RV being eliminated by antibody, the weight of the mice which were inoculated with SRV<SUB>9</SUB> could gradually recover.
ER  -