TY  - JOUR
T1  - Expression Differentiation of <I>BPI</I> Gene in Post-Weaning Piglets of Yorkshire, Sutai and Meishan Breeds
AU - Zhu, J. AU - Zi, C. AU - Su, X.M. AU - Liu, L. AU - Du, Z.D. AU - Ye, L. AU - Xie, K.Z. AU - Huang, X.G. AU - Wu, S.L. AU - Bao, W.B. 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 23
SP  - 3155
EP  - 3160
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.3155.3160
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.3155.3160
KW  - BPI gene
KW  -gene expression
KW  -pig
KW  -real-time PCR
KW  -bacteria
KW  -human
AB  - The Bactericidal/Permeability-Increasing protein (BPI) plays a very important role in the animal body&#146;s natural defense. It has a series of biological functions such as killing Gram-negative bacteria, the neutralization of endotoxin or lipopolysaccharides, etc. To investigate the effect and mechanism of porcine <I>BPI</I> gene on enterotoxigenic <I>Escherichia coli </I>F18, particularly whether the expression of<I> BPI</I> gene is related to the different breeds. In this study, real-time PCR was used to analyze the expression of <I>BPI </I>gene expression in post-weaning piglets of Yorkshire, Sutai (Resource Population of resistance to <I>E. coli</I> F18) and Meishan. The results showed that there was almost no expression or very low expression of <I>BPI</I> gene in heart, liver, spleen, lung, kidney, stomach, muscle, thymus and lymph nodes but there was a high expression in the duodenum and jejunum and the expression levels were significantly different from those of the other 9 organs. It also showed that the jejunum and duodenum expression of <I>BPI </I> gene in Sutai was significant higher than Yorkshire and Meishan (p&lt;0.05). The researchers can speculate that the expression of <I>BPI</I> gene was significant difference in different breeds. The researchers can further indicates that the expression of the <I>BPI</I> gene in Sutai piglets could be beneficial to the infection of <I>E. coli</I>. <I>BPI</I> gene might have a direct role against diarrhea and edema disease caused by ECF18 in weaned piglets, the resistance was related to the upregulation of <I>BPI</I> gene expression in the intestine. <I>BPI</I> gene can be identified as a genetic marker for future breeding against <I>E. coli </I>and Salmonella related diseases.
ER  -