TY  - JOUR
T1  - Effect of Long-Term Dietary Lipids on Femur Mineral Content, <I>Ex vivo</I> Prostaglandin E<SUB>2</SUB> Release and Bone Growth in Growing Rabbits
AU - Al-Nouri, D.M. AU - Al-Khalifa, A.S. 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 22
SP  - 2943
EP  - 2955
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.2943.2955
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.2943.2955
KW  - É-6 and É-3 PUFAs
KW  -bone minerals
KW  -prostaglandin
KW  -E2bone growth
KW  -growing rabbits
KW  -Saudi Arabia
AB  - The long-term effects of different dietary oil sources with varying omega-6/omega-3 (&#969;-6/&#969;-3) Polyunsaturated Fatty Acids (PUFAs) ratios on the bone marrow fatty acids level, bone growth and <I>ex vivo</I> Prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) release and minerals content in bone were evaluated in rabbits. Weanling male and female New Zealand white rabbits were randomly assigned to five groups and fed <I>ad libitum</I> on diets containing 70 g kg<SUP>-1</SUP> of added oil for 100 days as follow; Soybean Oil (SBO control), Sesame Oil (SO), Fish Oil (FO), DHA algae oil (DHA) and DHA and ARA algae oils (DHA/ARA). The dietary lipid treatments were formulated to provide the following ratio of &#969;-6/&#969;-3 fatty acids: 8.7 (SBO), 21.8 (SO), 0.4 (FO), 0.6 (DHA) and 0.7 (DHA/ARA). The bone marrow fatty acids level of rabbits was significantly influenced by and reflected the dietary level of &#969;-6 and &#969;-3 fatty acids fed to rabbits. Rabbits fed the FO diet maintained a lower &#969;-6/&#969;-3 ratio and a higher EPA and DHA concentrations in their bone marrow those fed the SO diet maintained a higher &#969;-6/&#969;-3 fatty acids ratio while those fed the SBO diet maintained a higher LA and ALA concentrations and intermediate value of &#969;-6/&#969;-3 ratio. <I>Ex vivo</I> PGE<SUB>2</SUB> level declined progressively as the &#969;-6/&#969;-3 dietary ratio declined. There was a significant main effect of dietary treatment on femur Ca, P, Mg and Zn contents in both genders. These results demonstrate that dietary &#969;-6/&#969;-3 ratio modulates bone PGE<SUB>2</SUB> production in growing rabbits, hence may reduce bone resorption and improve bone mass during growth. In addition, the significant elevation in mineral content and the maintenance of optimal Ca/P ratio in bone of DHA/ARA and DHA fed groups demonstrates that marine algae oils may be promising dietary sources for promoting bone mineralization and formation thus improving bone mass during the growth stage.
ER  -