TY  - JOUR
T1  - Postnatal Development of <I>IGF-I</I> and <I>IGF-II</I> Genes in Goat Skeletal Muscle and Liver Tissues
AU - Wang, Linjie AU - Li, Li AU - Wang, Bo AU - Zhang, Hongping 
JO  - Journal of Animal and Veterinary Advances
VL  - 10
IS  - 20
SP  - 2745
EP  - 2750
PY  - 2011
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2011.2745.2750
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2011.2745.2750
KW  - skeletal muscle
KW  -Goat
KW  -Nanjiang Mongolian Grazelle
KW  -IGF-I
KW  -IGF-II
KW  -liver
AB  - Insulin like Growth Factors (IGF-I and IGF-II) play an important role in regulation of skeletal muscle growth and act as mediator of growth hormone during muscle development and differentiation. In this study, the expression profiling of goat <I>IGF-I</I> and <I>IGF-II</I> genes was investigated in liver and skeletal muscle at six postnatal development stages (3, 15, 30, 60, 90 and 120 days) and two types of muscles (longissimus dorsi muscle, LD; triceps brachii muscle, TB) using relative real-time quantitative PCR. The results showed that <I>IGF-I</I> gene was expressed at the highest level in the liver with relatively high expression levels in spleen, skeletal muscle and heart. <I>IGF-II</I> gene was predominantly expressed in spleen, followed by liver and longissimus dorsi muscle, whereas expression in heart was relatively weak. <I>IGF-I</I> and <I>IGF-II</I> genes had different expression profiles during the postnatal period of the goat liver and skeletal muscle development. Moreover, <I>IGF-I</I> was expressed at higher levels in triceps brachii muscles compared with longissimus dorsi muscles. The present study provided the comprehensive understanding of IGF-I and IGF-II expression during liver and muscle development and laid the basis for further studies on their roles in goat liver and skeletal muscle development.
ER  -