TY - JOUR
T1 - Possible Association of Single Nucleotide Polymorphism in Titin Gene with Growth-Related Trait in Japanese Black Beef Cattle
AU - Murakami, Hiroshi AU - Morimatsu, Fumiki AU - Yamada, Takahisa AU - Sasaki, Seiki AU - Sukegawa, Shin AU - Takahagi, Youichi AU - Morita, Mitsuo AU - Fujita, Tatsuo
JO - Journal of Animal and Veterinary Advances
VL - 10
IS - 19
SP - 2603
EP - 2606
PY - 2011
DA - 2001/08/19
SN - 1680-5593
DO - javaa.2011.2603.2606
UR - https://makhillpublications.co/view-article.php?doi=javaa.2011.2603.2606
KW - beef cattle
KW -Association
KW -growth-related trait
KW -Japanese black breed
KW -single nucleotide polymorphism
KW -TTN
AB - Growth performance as well as marbling is the main breeding objectives in Japanese Black cattle, the major beef breed in Japan. The researchers have recently reported that a Single Nucleotide Polymorphism (SNP), referred to as g.231054C>T in promoter region of the Titin (TTN) gene was associated with marbling in Japanese Black beef cattle with the T allele being associated with a high level of marbling. The TTN is known to be involved in myofibrillogenesis and has been previously shown to be located within genomic region of a quantitative trait locus for rib eye area. Thus, the TTN was considered as a positional functional candidate for the gene responsible for growth performance. In this study, the researchers analyzed the effect of the TTN g.231054C>T SNP genotypes on the growth-related carcass traits in Japanese Black beef cattle. The SNP was marginally associated with rib eye area in two experiments using 101 sires (p = 0.067) and 820 paternal half-sib progeny steers from 3 sires homozygous for C allele at the g.231054C>T (p = 0.090) in Japanese Black beef cattle. These findings suggest possible effect of the g.231054C>T on the growth-related trait in Japanese Black beef cattle. The TTN SNP polymorphism may be useful for effective marker-assisted selection to increase the beef productivity in Japanese Black beef cattle.
ER -